3,4-Dihydro-2H-pyran (DHP, CAS 110-87-2) is a vital pharmaceutical intermediate prominently used in active pharmaceutical ingredient (API) synthesis. This six-membered heterocyclic ether serves a critical function as a protecting agent for hydroxyl groups through the formation of tetrahydropyranyl (THP) ethers. Its ability to mask alcohol functionalities under mild acidic conditions and revert them cleanly under aqueous acid makes it essential in multistep drug synthesis.
Manufactured via hydrogenation of dihydropyran or biomass-derived furfural, DHP aligns with green chemistry principles. Its dual role as a protecting reagent and reactive intermediate has cemented its value in the production of corticosteroids, macrolide antibiotics, and HIV protease inhibitors, among other high-value APIs.
| 3,4-Dihydro-2H-pyran | |
| CAS NO. | 110-87-2 |
| C5H8O | |
| 2932999099 | |
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>=98.5 |
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<=0.25 |
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1.3 max |
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| 0.922 |
DHP is used to selectively protect alcohol groups in drug intermediates as THP ethers. These groups are stable under basic and nucleophilic conditions and can be removed cleanly using dilute acids.
Facilitates synthesis routes where alcohol-containing intermediates must undergo further functionalization without side reactions.
DHP used for selective hydroxyl protection during ring formation.
Protects hydroxyl groups during complex ring rearrangements and oxidation steps.
In peptidomimetic drugs, DHP helps stabilize side chains during condensation and cyclization.
Can be derived from furfural-a biomass-based chemical-positioning DHP as a sustainable intermediate for pharmaceutical use.
Full-Cycle Safety Certifications
Steroidal drug synthesis (e.g., hydrocortisone, dexamethasone)
Selective hydroxyl protection in carbohydrate-based drug scaffolds
Process chemistry for scale-up of clinical candidates
Sealed in: 180 kg drums (bulk), 1L/5L bottles (laboratory or pilot scale)
A: It enables selective protection of hydroxyl groups, allowing multistep drug synthesis to proceed efficiently without side reactions.
A: Yes. High-purity pharma-grade DHP is suitable for regulated environments when supported by validated specifications and COAs.
A: THP groups are removed using mild acid (e.g., aqueous acetic acid), restoring the free alcohol for subsequent steps.
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|
|
>=98.5 |
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<=0.25 |
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1.3 max |
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| 0.922 |
ትኩስ መለያዎች: pharmaceutical intermediate 3,4-dihydro-2h-pyran, China pharmaceutical intermediate 3,4-dihydro-2h-pyran manufacturers, suppliers, factory
