3,4-Dihydro-2H-pyran (DHP, CAS 110-87-2) is a colorless, flammable liquid with a mild ether-like odor and serves as a foundational intermediate in organic synthesis. As a six-membered heterocyclic ether, DHP is best known for its role in protecting alcohol functionalities through tetrahydropyranyl (THP) ether formation. This makes it indispensable in multi-step synthesis of pharmaceuticals, natural products, and specialty chemicals.
Produced via catalytic hydrogenation of dihydropyran or biomass-derived furfural, DHP aligns well with the needs of sustainable chemistry. Its core properties-base stability, acid sensitivity, and volatility-also support its application in resins, coatings, and fine chemical production.
| 3,4-Dihydro-2H-pyran CAS 110-87-2 | |
| CAS NO. | 110-87-2 |
| C5H8O | |
| 2932999099 | |
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>=98.5 |
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<=0.25 |
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1.3 max |
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~-6℃ (closed cup) |
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Ether-like |
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180 kg drums, lab bottles |
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| 0.922 |
Usage & Core Function of 3,4-Dihydro-2H-pyran CAS 110-87-2
DHP forms THP ethers with alcohols under mild acid catalysis, rendering alcohols inert to nucleophiles and bases during complex synthetic procedures. THP groups are easily removed using dilute acids.
Used in the synthesis of steroids, HIV protease inhibitors, and macrolide antibiotics by selectively masking hydroxyl groups.
Precursor in the synthesis of flavors, fragrances (e.g., musk compounds), and agrochemicals.
Provides cyclic ether building blocks for high-performance coatings and UV-curable systems.
- Biomass-Derived Platform Molecule:
DHP can be synthesized from furfural, making it a viable intermediate in bio-based solvent and additive development.
Full-Cycle Safety Certifications
Pharmaceutical synthesis (e.g., erythromycin, corticosteroids)
UV-curable coatings and high-flex resins
Fuel additive synthesis (e.g., solketal route)
Sealed in: 180 kg drums (industrial), 1L/5L bottles (lab scale)
A: It is primarily used to protect alcohol groups as THP ethers during synthesis. This allows selective reactions to occur without interference from hydroxyl groups.
A: Yes. DHP can be produced from furfural, which is sourced from agricultural biomass waste like corncobs and bagasse.
A: THP groups are removed using dilute aqueous acid, regenerating the original alcohol with minimal side reactions.
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|
|
|
>=98.5 |
|
|
<=0.25 |
|
|
1.3 max |
|
|
~-6℃ (closed cup) |
|
|
Ether-like |
|
|
180 kg drums, lab bottles |
|
| 0.922 |
ትኩስ መለያዎች: 3,4-dihydro-2h-pyran cas 110-87-2, China 3,4-dihydro-2h-pyran cas 110-87-2 manufacturers, suppliers, factory
